The design and analysis of vaccine trials for emerging infectious disease threats; from Ebola to Covid 19, and now monkeypox - Professor Ira Longini - Department of Biostatistics, University of Florida
It is important to find vaccines and therapeutics for global infectious disease threats as rapidly as possible. The vaccine trail design should be randomized and adaptive to account for initially sporadic transmission of the emerging infectious disease. This design has been used to find a successful Ebola vaccine, and is now in the field to find more COVID-19 vaccines. Future vaccine trials will be for monkeypox, chikungunya, Zika and other infectious disease threats. In this talk, he will describe the statistical and operational components of a cluster randomized vaccine trial to find an emergency Ebola vaccine. He will describe the design and application of methods for Ebola transmission in Guinea, in terms of the statistical operating characteristics of the trial and analysis.
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